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Abstract Neutron-induced nuclear reactions play an important role in the Big Bang Nucleosynthesis. Their excitation functions are, from an experimental point of view, usually difficult to measure. Nevertheless, in the last decades, big efforts have led to a better understanding of their role in the primordial nucleosynthesis network. In this work, we apply the Trojan Horse Method to extract the cross section at astrophysical energies for the³He(n,p)³H reaction after a detailed study of the²H(³He,pt)H three-body process. Data extracted from the present measurement are compared with other published sets. The reaction rate is also calculated, and the impact on the Big Bang nucleosynthesis is examined in detail. 

Abstract Osteoarthritis is the third most rapidly growing health condition associated with disability, after dementia and diabetes¹. By 2050, the total number of patients with osteoarthritis is estimated to reach 1 billion worldwide². As no disease-modifying treatments exist for osteoarthritis, a better understanding of disease aetiopathology is urgently needed. Here we perform a genome-wide association study meta-analyses across up to 489,975 cases and 1,472,094 controls, establishing 962 independent associations, 513 of which have not been previously reported. Using single-cell multiomics data, we identify signal enrichment in embryonic skeletal development pathways. We integrate orthogonal lines of evidence, including transcriptome, proteome and epigenome profiles of primary joint tissues, and implicate 700 effector genes. Within these, we find rare coding-variant burden associations with effect sizes that are consistently higher than common frequency variant associations. We highlight eight biological processes in which we find convergent involvement of multiple effector genes, including the circadian clock, glial-cell-related processes and pathways with an established role in osteoarthritis (TGFβ, FGF, WNT, BMP and retinoic acid signalling, and extracellular matrix organization). We find that 10% of the effector genes express a protein that is the target of approved drugs, offering repurposing opportunities, which can accelerate translation. 

The ALICE Collaboration reports measurements of the large relative transverse momentum ( $k_T$) component of jet substructure in $pp$and Pb-Pb collisions at center-of-mass energy per nucleon pair $\sqrt{s_{\mathrm{NN}}}=5.02\mathrm{TeV}$. Enhancement in the yield of such large- $k_{\mathrm{T}}$emissions in head-on Pb-Pb collisions is predicted to arise from partonic scattering with quasiparticles of the quark-gluon plasma. The analysis utilizes charged-particle jets reconstructed by the anti- $k_{\mathrm{T}}$algorithm with resolution parameter $R=0.2$in the transverse-momentum interval $60<p_{\mathrm{T},\mathrm{ch},\mathrm{jet}}<80\mathrm{GeV}/c$. The soft drop and dynamical grooming algorithms are used to identify high transverse momentum splittings in the jet shower. Comparison of measurements in Pb-Pb and $pp$collisions shows medium-induced narrowing, corresponding to yield suppression of high- $k_T$splittings, in contrast to the expectation of yield enhancement due to quasiparticle scattering. The measurements are compared to theoretical model calculations incorporating jet modification due to jet-medium interactions (“jet quenching”), both with and without quasiparticle scattering effects. These measurements provide new insight into the underlying mechanisms and theoretical modeling of jet quenching. 

Abstract This paper presents a study of the inclusive forward J/ψyield as a function of forward charged-particle multiplicity in pp collisions at$$ \sqrt{s} $$ $\sqrt{s}$= 13 TeV using data collected by the ALICE experiment at the CERN LHC. The results are presented in terms of relativeJ/ψyields and relative charged-particle multiplicities with respect to these quantities obtained in inelastic collisions having at least one charged particle in the pseudorapidity range |η|<1. The J/ψmesons are reconstructed via their decay intoμ⁺μ⁻pairs in the forward rapidity region (2.5< y <4). The relative multiplicity is estimated in the forward pseudorapidity range which overlaps with the J/ψrapidity region. The results show a steeper-than-linear increase of the J/ψyields versus the multiplicity. They are compared with previous measurements and theoretical model calculations.